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doi:10.1146/annurev.pharmtox.45.120403.095857 [PubMed] 15

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Moreover, elevated systemic concentrations of TMAO enhanced thrombosis potential in vivo in animal models (4), and in recent clinical intervention studies, elevation in plasma TMAO induced with dietary choline supplementation altered platelet hyperresponsiveness in subjects (omnivores and vegans/vegetarians alike), as monitored by platelet aggregometry (17)